Mouse models of rhinovirus infection and airways disease

Title: Mouse models of rhinovirus infection and airways disease
Creator: Bartlett, Nathan W.; Singanayagam, Aran; Johnston, Sebastian L.
Relation: Rhinoviruses: Methods and Protocols p. 181-188
Relation: Methods in Molecular Biology 1221
Publisher Link: http://dx.doi.org/10.1007/978-1-4939-1571-2_14
Publisher: Springer
Resource Type: book chapter
Date: 2015
Description: Mouse models are invaluable tools for gaining insight into host immunity during virus infection. Until recently, no practical mouse model for rhinovirus infection was available. Development of infection models was complicated by the existence of distinct groups of viruses that utilize different host cell surface proteins for binding and entry. Here, we describe mouse infection models, including virus purification and measurement of host immune responses, for representative viruses from two of these groups: (1) infection of unmodified Balb/c mice with minor group rhinovirus serotype 1B (RV-1B) and (2) infection of transgenic Balb/c mice with major group rhinovirus serotype 16 (RV-16).
Subject: purification; major group; minor group; serotype; hela cells; in vivo infection
Identifier: http://hdl.handle.net/1959.13/1336930
Identifier: uon:27733
Language: eng

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